eng Science and Education Publishing American Journal of Clinical Medicine Research 2328-403X 2026-03-04 14 1 8 14 10.12691/ajcmr-14-1-2 AJCMR20261412 article Dr. Deepthi Dandu 1 Dr. Urmi Reshamdalal urmireshamdalal24@gmail.com 2 Dr. Irram Fatima 3 Dr. Syed Ammar Ali 4 Dr. Karen Michelle Izquierdo 5 Dr. Neha Sahu 6 Dr. Sandeep Singh 7 BDS, Sharavathi Dental College and Hospital, Shimoga. (Rajiv Gandhi University of Health Sciences) India BDS, Vaidik Dental College and Research Center, Daman, Gujarat, India BDS, Sri Balaji Dental College, Hyderabad, India Ms In Healthcare Informatics, University - Depaul University - 1 E Jackson Blvd, Chicago, IL 60604 DMD, Universidad Catolica de Santiago de Guayaquil, Av. Carlos Julio Arosemena BDS, RDH, Hitkarini Dental College and Hospital, Jabalpur, India MDS, Post Graduate Institute of Dental Sciences, Rohtak, India Background: Dental implants are a predictable and highly successful treatment modality; however, their long-term success is closely influenced by the patient¡¯s systemic health. As implant therapy is increasingly requested by medically compromised patients, understanding the impact of systemic conditions on implant outcomes is essential. Objective: This review aims to evaluate current evidence on the influence of systemic health conditions on dental implant success and to provide clinically relevant considerations for managing such patients. Methods: A literature search was conducted in PubMed, Scopus, and Embase, including clinical trials, cohort studies, and systematic reviews published over the past two decades that examined the relationship between systemic diseases and dental implant outcomes. Results: Several systemic conditions, including uncontrolled diabetes mellitus, cardiovascular disease, osteoporosis, obesity, autoimmune disorders, smoking, and chronic kidney or liver disease, were associated with impaired healing, compromised bone quality, and reduced implant stability. Additionally, medication-related factors such as bisphosphonate therapy and long-term immunosuppression were identified as contributing risks for implant-related complications. Conclusion: Systemic health status plays a critical role in dental implant success. Thorough medical evaluation, optimization of systemic conditions, and individualized treatment planning are essential to improve outcomes in medically compromised patients. Interdisciplinary collaboration and evidence-based decision-making are key to achieving safe and predictable implant therapy. https://pubs.sciepub.com/ajcmr/14/1/2/ajcmr-14-1-2.pdf Dental Implant Systemic Health Diabetes Osteoporosis