@article{ajcdr2024921,
author={{Abate, Desalegn Aychiluhm and Abdissa, Senbeta Guteta and Ayalew, Zekarias Seifu and Azibte, Gebeyehu Tessema and Ayele, Zelalem Belay},
title={Unlocking the Puzzle: Sex, Hypertension, and SGLT2 Inhibitors - Determinants of LDL-C Target Achievement in Coronary Heart Disease},
journal={American Journal of Cardiovascular Disease Research},
volume={9},
number={2},
pages={10--16},
year={2024},
url={https://pubs.sciepub.com/ajcdr/9/2/1},
abstract={<b>Background: </b>- Globally, cardiovascular diseases (CVD) are the primary cause of death. According to estimates, ischemic heart disease and cerebrovascular illnesses were responsible for 85% of 18 million CVD-related fatalities that occurred globally in 2017. One of the main causative risk factors for atherosclerotic cardiovascular disease is elevated low-density lipoprotein cholesterol (LDL-C). LDL particles can migrate from plasma into the subendothelial region of the artery, where they induce inflammation and lead to the development of atherosclerotic plaques. Thus, LDL-C lowering should be tailored to reach the target objective suggested by guidelines to reduce cardiovascular disease risk. <b>Objective: </b>-Assessment of low-density lipoprotein cholesterol target attainment and associated factors among patients with established coronary heart disease at the cardiology clinic, Tikur Anbessa Specialized Hospital. <b>Methods:</b> - Institutional-based retrospective cross-sectional study design was conducted from August 2023 to October 2023. In this study, among 240 planned participants, 221 participants were extracted, making a chart retrieval rate of 91.7%. Data analysis was done by using SPSS version 26. Multiple regression was applied to identify associated factors. <b>Result:</b> - In this study, about two-thirds of the participants were male, and more than one-third were between the ages of sixty-one and seventy. The level of LDL-C target attainment was 41%. The factors significantly associated with the LDL-C target attainment were male sex (AOR=1.8, 95%CI=1.44, 3.42), hypertension (AOR=0.57, 95%CI=0.31, 0.91), and taking SGLT2 inhibitors (AOR=1.5, 95%CI=1.37, 4.85). <b>Conclusion: </b>The level of LDL-C target attainment was low. Male sex and taking sodium-glucose transporter 2 (SGL2) inhibitors were favorable factors, but hypertension was associated with a low level of LDL target attainment.},
doi={10.12691/ajcdr-9-2-1}
publisher={Science and Education Publishing}
}