eng Science and Education Publishing American Journal of Biomedical Research 2328-3955 2025-09-23 13 2 20 28 10.12691/ajbr-13-2-1 AJBR20251321 article NGOUNBE RILENGAR L¨Ļon ngounber2021@gmail.com 1 Hal Souakar AMBERA 1 Kakesse MAGUIRGUE 2 Brahim Boy OTCHOM 2 University of N'Djamena, Doctoral School of Sciences-Techniques-Environment, Doctoral Training in Biology and Human Health, Research Laboratory, Diagnostics and Scientific Expertise, Toxicology and Pharmacology Unit, Chad University of Sarh, Faculty of Science and Technology, Department of Life and Earth Sciences, Biology Laboratory, Toxicology and Pharmacology Unit, Chad Our study consisted of evaluating the antiatherosclerotic activity of Raphionacme brownii tubers. The antiatherosclerotic activities were evaluated on rats, subdivided into two phases including the induction of hypercholesterolemia for 30 days and the treatment of hypercholesterolemia for 15 days. The evaluation of the antiatherosclerotic activity revealed a significant decrease in TC to 44.28% in females and 47.98% in males; TG to 34.48% in females and 26.66% in males; LDL to 45.16% in females and 41.30% in males and conversely an increase in HDL to 14.58% in females and 20.75% in males. The atherogenic index showed a better activity of the effect of Raphionacme brownii tubers on atherosclerosis. The richness in bioactive compounds could justify the traditional use of Raphionacme brownii as a hypolipidemic agent treating cardiovascular diseases. https://pubs.sciepub.com/ajbr/13/2/1/ajbr-13-2-1.pdf Raphionacme brownii secondary metabolites and atherosclerosis