Science and Education Publishing American Journal of Applied Psychology 2333-4738 5 1 2017 1 23 Association between Psychological Wellbeing and Antiretroviral Therapy Adherence in North-Central, Nigeria 18 24 EN Modupe Oladunni Taiwo Department of Psychology Obafemi Awolowo University, Ile-Ife, Nigeria Funmi-Togonu Bickersteth AJAP2017514 10.12691/ajap-5-1-4 2016 10 8 2016 12 5 2017 1 21 Psychological wellbeing of antiretroviral patients in Nigeria is under researched despite being a critical success factor in ART adherence. Using a sample of antiretroviral therapy patients (n=641) from six clinics in North central Nigeria in a cross sectional mixed method approach, we examined the domain of psychological wellbeing that is associated with ART adherence. ART adherence was 88%. Environmental mastery (84.4%), Autonomy (73.2%) and Self-acceptance (65.4%) were associated with higher ART adherence. Among sociodemographic characteristics, only states of residence (X2 = 26.0841, p<.05) was significant. Cognitive behavioural therapy by a skilled psychologist is crucial for empowering ART patients to maintain optimal ART adherence.