T Sudhakar¹, Sabitha Kandi², B Venugopal², K. Bhagwan Reddy³, K V Ramana^4,

Hypothyroidism is a thyroid deficient state which shows its influence on other metabolic pathways whereas sub-clinical hypothyroidism (SCH) is a condition where there is decreased secretion of Thyroid Stimulating Hormone (TSH) with no significant clinical symptoms. Thyroid hormones (T_3, T₄ and TSH) play an effective role in various aspects of metabolism, development and differentiation of cells. In the present study which included 558 male subjects who came for regular health checkup, 68 (12.18%) were newly diagnosed as suffering from hypothyroidism and among them, 27 (4.83%) had altered lipid parameters. The presenting symptoms included unknown cause of fatigue and weight gain. The atherogenic lipid abnormalities in subjects with hypothyroidism in Indians should be interpreted with paramount importance as there is unexpected improvement or worsening of their lipid profile which may be influenced by abnormal thyroid hormone secretion. The altered lipid profile is seen in conditions where TSH is more than 10 mIU/ml which can result in increased risk of cardiac diseases and altered hemodynamic states. Alcoholism, smoking, sedentary life style, genetic predisposition and stress are added factors to earlier onset of SCH. The important aspects in management of thyroid diseases include the public health awareness, regular screening for the presence of dyslipedemia and thyroid function tests.

subclinical hypothyroidism (SCH), altered lipid parameters in hypothyroidism, cardiometabolic risk in hypothyroidism