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Hegde K, Joshi AB. Hepatoprotective and antioxidant effect of Carissa spinarum root extract against CCl4 and paracetamol-induced hepatic damage in rats. Bangladesh J Pharmacol. 2010; 5: 73-76.

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Article

Hepatoprotective Activity of Ethanol Extract of Conyza bonariensis against Paracetamol Induced Hepatotoxicity in Swiss Albino Mice

1College of Pharmacy, GC University, Faisalabad, Pakistan

2Department of Biochemistry, Hazara University, Mansehra, KPK, Pakistan

3Department of Pharmacology, Independent University Hospital, Faisalabad, Pakistan


American Journal of Medical and Biological Research. 2014, Vol. 2 No. 6, 124-127
DOI: 10.12691/ajmbr-2-6-2
Copyright © 2014 Science and Education Publishing

Cite this paper:
Mohammad Saleem, Faiza Naseer, Sohail Ahmad, Attiya Nazish, Fiza Raza Bukhari, Atta Ur Rehman, Imran Mahmood Khan, Samra Sadiq, Fatima Javed. Hepatoprotective Activity of Ethanol Extract of Conyza bonariensis against Paracetamol Induced Hepatotoxicity in Swiss Albino Mice. American Journal of Medical and Biological Research. 2014; 2(6):124-127. doi: 10.12691/ajmbr-2-6-2.

Correspondence to: Mohammad Saleem, College of Pharmacy, GC University, Faisalabad, Pakistan. Email: saleem2978@hotmail.com

Abstract

The hepatoprotective activity of Conyza bonariensis ethanol extract was studied against paracetamol induced hepatotoxicity in mice. The results showed that an extract of C.B (250 mg/kg and 500 mg/kg) produced (p<0.05) decline in paracetamol induced liver marker enzymes and total bilirubin, but its 750 mg/kg showed remarkable decline in ALT, AST, ALP and TB levels, compared to the reference levels of silymarin and results were supported by histopathology of liver section. So, it is concluded that 750 mg/kg is highly potent dose of ethanol extract of Conyza bonariensis and this potential may be due to the presence of the active constituent: qurecetin and chromatogram by HPLC confirmed its presence.

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