Article citationsMore >>

Maynard Se, Min JY, Merchan J, Lim KH, Li J, Mondal S et. Al., Excess placental soluble fms – like tyrosine kinase 1 (sFlt – 1) may contribute to endothelial dysfunction, hypertension and proteinuria in pre eclampsia. J Clin Invest; 2003;111:649-58.

has been cited by the following article:

Article

Pre Eclampsia: Its Effect on Renal, Cardiovascular, Hepatic and Thyroid Functions a Review

1Department of Biochemistry, Chalmeda Anandrao Institute of Medical Sciences, Karimnagar, India

2Department of Obstetrics and Gynaecology, Chalmeda Anandrao Institute of Medical Sciences, Karimnagar, India

3Department of Biochemistry, Kasturba Medical College, Manipal University, Manipal, India

4Department of Microbiology, Prathima Institute of Medical Sciences, Karimnagar, India


American Journal of Clinical Medicine Research. 2014, Vol. 2 No. 6, 111-113
DOI: 10.12691/ajcmr-2-6-2
Copyright © 2014 Science and Education Publishing

Cite this paper:
Sabitha kandi, B Venu Gopal, Raj Kumar G, MD Rafi, T Sudhakar, C Ramadevi, Mamatha, Pragna Rao, K V Ramana. Pre Eclampsia: Its Effect on Renal, Cardiovascular, Hepatic and Thyroid Functions a Review. American Journal of Clinical Medicine Research. 2014; 2(6):111-113. doi: 10.12691/ajcmr-2-6-2.

Correspondence to: K  V Ramana, Department of Microbiology, Prathima Institute of Medical Sciences, Karimnagar, India. Email: ramana_20021@rediffmail.com

Abstract

Preeclampsia is a severe disorder of pregnancy characterized by the development of hypertension and proteinuria, increased vascular resistance and endothelial dysfunction in the mother, altered placental perfusion and restricted fetal growth. There is increased release of soluble growth factor like sFlt 1 from placenta, which decreases the availability of Vascular Endothelial Growth Factor(VEGF) receptors and decreases the availability of endothelial Nitric Oxide synthase. This inturn decreases the diastolic relaxation and endothelial dysfunction, podocyte injury of glomerular cells, increased excretion of podocyte specific proteins in urine leads to proteinuria. Cardiac hypertrophy further complicates the heart function. There is a raise in liver function; soluble factor like tyrosine kinase 1 (sFlt 1) may cause a disturbance in thyroid hormone function, thus prone to thyroid problem during or after pregnancy.

Keywords