Article citationsMore >>

Cetiner M, Sener G, Sehirli AO, Eksioglu-Demiralp E, Ercan F, Sirvanci S, Gedik N, Akpulat S, Tecimer T, Yegen BC. Taurine protects against methotrexate-induced toxicity and inhibits leucocyte death. Toxicol Appl Pharmacol 2005: 209 (1): 39-50.

has been cited by the following article:

Article

Methotrexate-induced Hepatic and Renal Toxicity: Role of L-carnitine in Treatment

1Zoology Department, Faculty of Science, Tanta University, Tanta 31527, Egypt

2Zoology Department, Faculty of Science, Alazhar University, Cairo, Egypt


Biomedicine and Biotechnology. 2014, Vol. 2 No. 4, 85-92
DOI: 10.12691/bb-2-4-4
Copyright © 2014 Science and Education Publishing

Cite this paper:
Ehab Tousson, Zaki Tawfeek Zaki, Walid Ali Abu-Shaeir, Hamada Hassan. Methotrexate-induced Hepatic and Renal Toxicity: Role of L-carnitine in Treatment. Biomedicine and Biotechnology. 2014; 2(4):85-92. doi: 10.12691/bb-2-4-4.

Correspondence to: Ehab  Tousson, Zoology Department, Faculty of Science, Tanta University, Tanta 31527, Egypt. Email: toussonehab@yahoo.com

Abstract

Methotrexate (MTX) is used as a chemotherapeutic agent used to treat many cancer types. The present study aimed to examine the possible modifying effects of l-carnitine against hepatic and renal toxicity induced by MTX in rats. A total 60 male albino rats were equally divided into six groups; the first and second groups were the control and l-carnitine groups respectively while the 3rd group was MTX rat group; the 4th and 5th groups were co- and post treated MTX rat with l-carnitine respectively and the 6th group was MTX self treated rat group. A significant increase in serum ALT, AST, urea, creatinine, uric acids and MDA levels and significant decrease GSH, catalase and total protein in MTX and self healing groups when compared with control and l-carnitine groups. In contrast, MTX-treated with l-carnitine exhibited a significant decrease in serum ALT, AST, urea, creatinine, uric acids and MDA levels and significant increase GSH, catalase and when compared with total protein in MTX and self healing groups. Histopathological results supported the biochemical results and the ameliorating effect of l-carnitine on liver and kidney toxicities. L-carnitine possessed various protective mechanisms against MTX-induced liver and kidney toxicity throughout co- and post treatment. We can conclude that treatment with l-carnitine during the MTX chemotherapy has beneficial properties and can reduce the liver and kidney toxicity induced by MTX.

Keywords