İsmail Özkaya^1,, Işıl Bavunoglu², Aydın Tunçkale²

Study Design: Obesity prevalence is incresing in Turkish population whose lipoprotein profile is characterised by low levels of HDL cholesterol. Our study aims to determine how obesity changes lipid profiles in Turkish women. Materials and Methods: We evaluated 2501 overweight and obese adult women. After systemic physical examination and some antropometric studies, blood samples have been analysed for lipid parameters. Results: Body mass index (BMI), trigliserides (TG), very low density lipoprotein-cholesterol (VLDL-C), nonhigh density lipoprotein-cholesterol (NHDL- C), TG/HDL-C ratio, total cholesterol (TC)/HDL-C ratio and LDL-C/HDL-C ratio are significantly increased (p<0,05), but HDL-C levels are significantly decreased (p<0,05) in study population. There was a negative correlation between HDL-C and BMI, waist circumference, TG and homeostasis model assessment-insulin resistance (HOMA-IR) (p<0,05). On the other hand, there was a positive correlation between HDL-C with age, TC (p<0,05) and between abdominal circumference with TG, NHDL-C, TG/HDL-C ratio, TC/HDL-C ratio and LDL-C/HDL-C ratio (p<0,05). Similarly, there was also a positive correlation between BMI with some lipid parameters (TG, VLDL-C, NHDL- C, TG/HDL-C ratio, TC/HDL-C ratio and LDL-C/HDL-C ratio (p<0,05). The patients are separated into two groups as metabolic syndrome positive (MS+) and negative (MS-) and then compared. HDL-C in MS+ group was significantly lower than MS- group (p<0,05). Other all parameters in MS+ group were significantly higher than MS- group (p<0,05). Conclusion: Increase of abdominal circumference and HOMA-IR has a negative effect on lipid parameters. Additionally, BMI has similarly negative effect on some lipid parameters in Turkish women.

Obesity, waist circumference, lipid and lipoproteins