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Sander, J.W, The epidemiology of epilepsy revisited. Curr Opin Neurol, 2003, 165-170.

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Article

Screening of the Anticonvulsant Activity of Some Isatin Derivatives in Experimental Seizure Models and Its Effect on Brain GABA Levels in Mice

1Department of Biotechnology, AcharyaNagarjuna University, Guntur, India

2Vaagdevi College of Pharmacy, Hanamkonda, Warangal, India

3TallaPadmavathi College of Pharmacy, Orus, Warangal, India


American Journal of Pharmacological Sciences. 2013, Vol. 1 No. 3, 42-46
DOI: 10.12691/ajps-1-3-3
Copyright © 2013 Science and Education Publishing

Cite this paper:
Venkateshwarlu Eggadi, Umasankar Kulandaivelu, Sharvanabhava B S, Venkateshwar Rao Jupally. Screening of the Anticonvulsant Activity of Some Isatin Derivatives in Experimental Seizure Models and Its Effect on Brain GABA Levels in Mice. American Journal of Pharmacological Sciences. 2013; 1(3):42-46. doi: 10.12691/ajps-1-3-3.

Correspondence to: Venkateshwar Rao Jupally, TallaPadmavathi College of Pharmacy, Orus, Warangal, India. Email: eggadivenkey@gmail.com

Abstract

The modern therapeutic approaches of antiepileptic agents against epileptic patients are showing many side effects, dose related effects and chronic toxicity. The aim of our present work is to evaluate anticonvulsant activity of isatin derivatives (Ia-Ij) to reduce the side-effects and increase the percentage protection from various stages of convulsions. No animals showed toxic effects even up to 2000mg/kg. It is evident that Ib, Ie, Ih, Ii and Ij showed anticonvulsant effect at the dose levels of 10 and 100mg/kg in MES test and except Ij all other derivatives exhibited antiepileptic effect at 10 and 100mg/kg in PTZ induced convulsions test. The isatin derivatives (Ib, Ie, Ih and Ii) which proved antiepileptic effect in both MES and PTZ induced convulsion models are selected and GABA levels in brain were estimated. They showed significant increase of GABA levels in brain.

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