1Department of Biochemistry, Chalmeda Anandarao Institute of Medical Sciences, Karimnagar, India
2Department of Biochemistry, Government Medical College, Nagpur, India
3Department of Bio-chemistry, Vaidehi Institute of Medical Sciences, and Research Centre, Bangalore, India
4Department of Biochemistry, Kamineni Institute of Medical Sciences, Narketpally, India
5Department of Biochemistry, Kasturba Medical College, Manipal University, Manipal, India
6Department of Microbiology, Prathima Institute of Medical Sciences, Karimnagar, India
American Journal of Medical Sciences and Medicine.
2014,
Vol. 2 No. 3, 64-66
DOI: 10.12691/ajmsm-2-3-3
Copyright © 2014 Science and Education PublishingCite this paper: Sabitha Kandi, Neelesh Deshpande, Venkata Bharath Kumar Pinnelli, Ramakrishna Devaki, Pragna Rao, K V Ramana. Alcoholism and Its Role in the Development of Oxidative Stress and DNA Damage: An Insight.
American Journal of Medical Sciences and Medicine. 2014; 2(3):64-66. doi: 10.12691/ajmsm-2-3-3.
Correspondence to: K V Ramana, Department of Microbiology, Prathima Institute of Medical Sciences, Karimnagar, India. Email:
ramana_20021@rediffmail.comAbstract
Alcohol is detoxified in the liver by the enzymes alcohol dehydrogenase and aldehyde dehydrogenase. The available literature suggests that activity of aldehyde dehydrogenase is less than alcohol dehydrogenase among Asians; hence it leads to accumulation of acetaldehyde during excess intake of alcohol. Accumulated acetaldehyde due to its electrophilic nature forms adducts with proteins and DNA. The acetaldehyde-DNA adduct (N-2-Ethyl deoxyguanosine (NDG)) induces mutations in DNA and leads to DNA damage. Prevention of excessive accumulation of acetaldehyde can be useful in decreasing the genotoxicity.
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