Lari Sapoznikov¹, Martin Humphrey^2,

Tooth dentin-derived autogenous bone graft material is very effective for dental bone defect repair but is limited by the need for sufficient material. A xenogeneic material with retained organic matrix, Ivory Dentin Graft, has thus been developed. The properties of this material in comparison to a bone-derived material were examined in a clinically relevant porcine model. Using a split-mouth design, two types of bone defects were created and grafted using either Ivory Dentin Graft or a bone-derived material with retained organic component. The extraction site of an extracted mandibular incisor modelled post-extraction socket preservation, while a mandibular sub-periosteal pouch modelled bone augmentation in procedures such as sinus lifting. At 10 weeks after grafting, when new bone growth and site remodeling is active, the graft sites were solid, dense and stable with no sign of loose particles with both materials. The dentin-derived material was distinguished by having a much higher mean percentage of intimate contact between the graft material and new bone growth (77.5% versus 45.5%) which was statistically different (p < 0.001, paired t-test, 2-tailed). This confirms that Ivory Dentin Graft retains the key property of autologous dentin, of forming an ankylosed network with new bone ingrowth which is key for early and maintained graft site stability.

bone graft, bone, dentin, tooth, material, orthopedic, dental, xenogeneic, osteoinductive, ankylosis, animal model, implant