Anamika Saroj^1,, Mukta Singh¹, L. P. Meena^2,, Ajay Kumar Choudhary³

Objective: The study investigates the link between Hyperuricemia, Body mass index (BMI) and Metabolic syndrome in middle-aged adults, providing insights for future interventions to prevent metabolic syndrome. Methods: A study was conducted between the periods July 2023 to March 2024 at the Department of General Medicine, Sir Sunder Lal Hospital, Banaras Hindu University (BHU), Varanasi, Uttar Pradesh, India among the adults in Eastern Uttar Pradesh and South Bihar. A total of 102 adult subjects aged 35 to 65 years were selected using sampling approach. The data collection included anthropometric measurements (height, weight, body mass index), blood pressure assessment and relevant biochemical investigations, which include fasting blood sugar (FBS), postprandial blood sugar (PPBS), glycated haemoglobin (HbA1c) and serum uric acid (SUA) levels. Furthermore, well-designed interview-based questionnaires were re-used to obtain sociodemographic and lifestyle information. All measurements were conducted under protocols and diagnosis of metabolic syndrome was evaluated based on recognized diagnostic criteria. Statistical analyses were carried out to assess the correlation between hyperuricemia, BMI and metabolic syndrome. A p-value of less than 0.05 was considered statistically significant. Results: The study revealed a significant association between hyperuricemia, increased adiposity and critical components of metabolic risk. Subjects aged between 46 to 55 years showed higher prevalence of increased serum uric acid (SUA) levels along with a maximum occurrence of metabolic irregularities. The dietary patterns and physical activity parameters of subjects were found to be profoundly modified with socio-demographic and lifestyle modifications. Additionally, hyperuricemia revealed a significant association with increased blood pressure and poor glycemic control, emphasizing its potential relation to the initial stage of metabolic syndrome. Conclusion: A systematic approach towards the nutritional pattern and physical activity criterion of subjects was profoundly modified with socio-demographic and lifestyle modifications. As follows, early detection of elevated uric acid levels and lifestyle interventions (diet, exercise, weight control) are essential to prevent the progression of metabolic complications. However, high blood pressure and blood sugar control are also essential for preventing metabolic syndrome consequences. Subjects that approach all of these variables systematically can significantly prevent their risk of suffering from crucial health problems associated with hyperuricemia.

BMI, Hyperuricemia, Lifestyle Modifications, Metabolic Syndrome, Socio-demographic