1Department of Pharmaceutical Chemistry and Drug Design, S. D. College of Pharmacy and Vocational Studies, Muzaffarnagar, India
American Journal of Pharmacological Sciences.
2014,
Vol. 2 No. 2, 37-41
DOI: 10.12691/ajps-2-2-2
Copyright © 2014 Science and Education PublishingCite this paper: Ajeet, Arvind Kumar. Designing, Proposed Synthesis and Docking Analysis of Novel Sulfonamide Derivatives as Antimicrobial Agents.
American Journal of Pharmacological Sciences. 2014; 2(2):37-41. doi: 10.12691/ajps-2-2-2.
Correspondence to: Ajeet, Department of Pharmaceutical Chemistry and Drug Design, S. D. College of Pharmacy and Vocational Studies, Muzaffarnagar, India. Email:
ajeet_pharma111@rediffmail.comAbstract
Substituted N-acetyl-4-amino-benzenesulfonamide derivatives were designed using ChemDraw Ultra 7.0 and energy minimization of derivatives was achieved with Chem3D Pro of ChemOffice suit, keeping in view the structural requirements of pharmacophore. Their proposed synthesis along with in-silico study (docking analysis) in favor of antimicrobial activity has been shown in this work with the possible mechanism of reaction. Docking studies were carried out to study the binding properties of drugs with molecular targets with the help of AutoDock Vina (Python-Prescription 0.8). Titled compounds (CS, DPS, SRS and TS) exhibited good binding properties with molecular target pseudomonas aeruginosa exotoxin A in Lamarckian genetic algorithm based flexible docking studies.
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