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Zhang, J.; Xu, M.; Zhou, W.; Li, D.; Zhang, H.; Chen, Y.; Ning, L.; Zhang, Y.; Li, S.; Yu, M.; Chen, Y.; Zeng, H.; Cen, L.; Zhou, T.; Zhou, X.; Lu, C.; Yu, C.; Li, Y.; Sun, J.; Kong, X.; Shen, Z., Deficiency in the anti-apoptotic protein DJ-1 promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via p53. J Biol Chem 2020, 295, (13), 4237-4251.

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Article

Role of PARK7/DJ-1 in Gastrointestinal Diseases

1Pediatric Center, MTA Center of Excellence, Semmelweis University, 1083 Budapest, Hungary

2HUN-REN-SE Pediatrics and Nephrology Research Group, 1052 Budapest, Hungary


International Journal of Celiac Disease. 2024, Vol. 12 No. 1, 28-32
DOI: 10.12691/ijcd-12-1-6
Copyright © 2024 Science and Education Publishing

Cite this paper:
Domonkos Pap, Apor Veres-Székely, Beáta Szebeni, Zrufkó Réka, Péter Bokrossy, Csenge Szász, Ádám Vannay. Role of PARK7/DJ-1 in Gastrointestinal Diseases. International Journal of Celiac Disease. 2024; 12(1):28-32. doi: 10.12691/ijcd-12-1-6.

Correspondence to: Ádám  Vannay, Pediatric Center, MTA Center of Excellence, Semmelweis University, 1083 Budapest, Hungary. Email: vannay.adam@semmelweis.hu

Abstract

Parkinson’s disease 7 (PARK7/DJ-1) is an evolutionarily conserved multifunctional protein whose role has been widely demonstrated in malignant tumours and neurodegenerative diseases, including Parkinson's or Alzheimer's disease. However, recent studies also revealed protective role of PARK7/DJ-1 regarding gastrointestinal diseases. In the present review, we discuss our current knowledge about PARK7/DJ-1 in the context of coeliac and inflammatory bowel disease.

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