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Article

Role of PARK7/DJ-1 in Gastrointestinal Diseases

Domonkos Pap^{1, 2}, Apor Veres-Székely^{1, 2}, Beáta Szebeni^{1, 2}, Zrufkó Réka^{1, 2}, Péter Bokrossy^{1, 2}, Csenge Szász^{1, 2}, Ádám Vannay^{1, 2,}

¹Pediatric Center, MTA Center of Excellence, Semmelweis University, 1083 Budapest, Hungary

²HUN-REN-SE Pediatrics and Nephrology Research Group, 1052 Budapest, Hungary

International Journal of Celiac Disease. 2024, Vol. 12 No. 1, 28-32
DOI: 10.12691/ijcd-12-1-6
Copyright © 2024 Science and Education Publishing

Cite this paper:
Domonkos Pap, Apor Veres-Székely, Beáta Szebeni, Zrufkó Réka, Péter Bokrossy, Csenge Szász, Ádám Vannay. Role of PARK7/DJ-1 in Gastrointestinal Diseases. International Journal of Celiac Disease. 2024; 12(1):28-32. doi: 10.12691/ijcd-12-1-6.

Correspondence to: Ádám  Vannay, Pediatric Center, MTA Center of Excellence, Semmelweis University, 1083 Budapest, Hungary. Email: vannay.adam@semmelweis.hu

Abstract

Parkinson’s disease 7 (PARK7/DJ-1) is an evolutionarily conserved multifunctional protein whose role has been widely demonstrated in malignant tumours and neurodegenerative diseases, including Parkinson's or Alzheimer's disease. However, recent studies also revealed protective role of PARK7/DJ-1 regarding gastrointestinal diseases. In the present review, we discuss our current knowledge about PARK7/DJ-1 in the context of coeliac and inflammatory bowel disease.

Keywords

PARK7/DJ-1, coeliac disease, inflammatory bowel disease, Crohn’s disease, ulcerative colitis