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Fonkem E, Lok E, Robison D, Gautam S, Wong ET. The natural history of intravascular lymphomatosis. Cancer Med. 2014; 3(4): 1010-1024.

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Article

Intravascular Large B–cell Lymphoma Diagnosed Incidentally after a Renal Biopsy: A Case Report of a Rare and Elusive Malignancy

1Wayne State University School of Medicine, Detroit, MI, USA

2Henry Ford Hospital, Wyandotte, MI, USA


American Journal of Medical Case Reports. 2024, Vol. 12 No. 9, 141-143
DOI: 10.12691/ajmcr-12-9-3
Copyright © 2024 Science and Education Publishing

Cite this paper:
Sikander Chohan, Shahina Patel. Intravascular Large B–cell Lymphoma Diagnosed Incidentally after a Renal Biopsy: A Case Report of a Rare and Elusive Malignancy. American Journal of Medical Case Reports. 2024; 12(9):141-143. doi: 10.12691/ajmcr-12-9-3.

Correspondence to: Sikander  Chohan, Wayne State University School of Medicine, Detroit, MI, USA. Email: ga7975@wayne.edu

Abstract

Intravascular large B-cell lymphoma (IVLBCL) is a form of diffuse large B-cell lymphoma (DLBCL) characterized by the proliferation of malignant B-cells within the lumen of small blood vessels. With an incidence rate of one in a million, it is one of the rarest forms of DLBCL. This rarity, combined with the absence of extravascular tumor masses or circulating malignant cells in the peripheral blood and potential involvement of multiple organs, makes the diagnosis of IVLBCL exceptionally difficult. We discuss that case of a 64-year-old female who presented with symptoms of altered mental status, expressive aphasia, and fatigue. She was also found to have normocytic anemia with elevated hemolysis markers. Over a period of months, her neurological symptoms and anemia with elevated hemolysis markers persisted despite repeated hematological, infectious, and neurological workup. Overall, we hope to highlight the unusual clinical manifestations of IVLBCL, as early diagnosis and treatment can be lifesaving.

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