Article citationsMore >>

Teng A.E., Noor B., Ajijola O.A., et al. Chemotherapy and Radiation-Associated Cardiac Autonomic Dysfunction. Curr Oncol Rep. 2021 Jan 8; 23(2): 14.

has been cited by the following article:

Article

Autonomic Dysfunction Induced by Single Cycle Combination Therapy with Paclitaxel-Cisplatin

1Department of Neurology, University of Texas Medical Branch Galveston, Texas

2Department of Neuro Oncology, MD Anderson Cancer Centre, Texas


American Journal of Medical Case Reports. 2024, Vol. 12 No. 5, 78-80
DOI: 10.12691/ajmcr-12-5-3
Copyright © 2024 Science and Education Publishing

Cite this paper:
Nithisha Thatikonda, Merry Chen. Autonomic Dysfunction Induced by Single Cycle Combination Therapy with Paclitaxel-Cisplatin. American Journal of Medical Case Reports. 2024; 12(5):78-80. doi: 10.12691/ajmcr-12-5-3.

Correspondence to: Nithisha  Thatikonda, Department of Neurology, University of Texas Medical Branch Galveston, Texas. Email: nithatik@utmb.edu

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) involving the autonomic nervous system (ANS) is frequently reported in the literature next to somatic sensory neuropathies. A few chemotherapy agents, such as platinum-based compounds and taxanes, are known to cause dose-dependent cumulative neurotoxicity, wherein autonomic symptoms develop gradually throughout treatment. However, when these chemotherapeutic agents are administered together as a part of a chemotherapy regimen, possible synergistic neurotoxicity is anticipated, even with a single course of treatment. We described a patient who developed severe autonomic dysfunction resulting in neurogenic orthostatic hypotension (nOH) and paralytic ileus after receiving only a single course of paclitaxel-ifosfamide-cisplatin (TIP) regimen for recurrent testicular cancer. The patient was bedridden for six weeks with slow recovery and remained with nOH for three months after discharge. Monitoring ANS parameters (blood pressure, heart rate, and their alterations upon standing) and timely identification of autonomic dysfunction is crucial to introducing treatment modifications/cessations accordingly.

Keywords