Yongping Liu¹, Siyou Tan¹, Lai Wei¹, Wenyan Chen^1,

This study aimed to investigate the effect of dexmedetomidine (Dex) combined with remote ischemic preconditioning (RIPC) on hepatic ischemia-reperfusion injury (HIRI) in patients undergoing hepatectomy. This study was designed as a prospective trial including ASA I-III patients aged 18 to 65 years scheduled for elective laparoscopic hepatectomy. Patients were randomly divided into two groups with 8 cases in each group: control and Dex combined with RIPC (DR) group. Information was collected regarding gender, age, height, weight, portal triad clamping time, operation time, intraoperative infusion volume, blood loss, and urine volume. Venous blood was collected after reperfusion to detect serum IL-6, ALT, AST, and TBIL. No difference was found in baseline information among the two groups (P > 0.05). Among the two groups, the serum level of ALT and AST in group DR was significantly decreased compared with the controls (p < 0.05), and the differences in postoperative serum IL-6 and TBIL levels between the two groups were not statistically significant (P > 0.05). The study demonstrated that the combined use of Dex and RIPC could alleviate HIRI caused by blocking the hepatic portal during laparoscopic hepatectomy.

Hepatic Ischemia-reperfusion Injury, Dexmedetomidine, Remote Ischemic Preconditioning, Hepatectomy