Zhaohui Liu¹, Tingting Su^2,

Background: Left ventricular dysfunction were mainly caused by acute ST-elevation myocardial infarction (STEMI), often indicates a poor prognosis of cardiac arrest or sudden cardiac death. There were up to 50% patients with acute STEMI developed to left ventricular dysfunction even with the timing of coronary revascularization and mortality continues to rise in this population. The SYNTAX score is a new system that calculates risk on the basis of the complexity of coronary artery anatomy and is used to select the optimal technique for revascularization in patients with significant coronary artery disease. This observational study aimed to investigate the associations of SYNTAX score and left ventricular dysfunction caused by acute STEMI. Methods: 198 patients admitted to the Cardiovascular Center of the Seventh Affiliated Hospital of Sun Yat-Sen University because of acute STEMI from 1 January 2022 to 31 December 2022, who subsequently underwent emergency or elective coronary angiography (CAG) or percutaneous coronary intervention (PCI), were included in this study. According to left ventricular dysfunction patients were divided into two groups as the group1 of left ventricular dysfunction and the group2 of normal left ventricular function. SYNTAX score was calculated immediately after the CAG to assess the complexity and severity of coronary artery disease. Results: We included 198 hospitalizations for acute STEMI with a mean age of 57.0 ± 13.3 years, 14.3% patients were female. There were 43 patients in group1 and 153 patients in group2. The baseline characteristics of the study population are shown in . There was significant difference between the two groups with SYNTAX score, white blood cell (WBC) count, neutrophil count, urea, estimated glomerular filtration rate (eGFR), high density lipoprotein cholesterol (HDL-C), N-terminal pro-B-type natriuretic peptide (NT-proBNP), cardiac troponin I (cTnI), creatine kinase-MB (CK-MB), and in-hospital mortality. Univariate and Multivariable regression models suggested that SYNTAX score was an independent risk factor for left ventricular dysfunction. The fitted curve indicates a linear relationship between SYNTAX score and left ventricular dysfunction. Conclusion: SYNTAX score was an independent risk factor for left ventricular dysfunction in patients with acute STEMI, and the relationship between them are negative.

coronary artery disease, Acute ST-elevation myocardial infarction, SYNTAX score, left ventricular dysfunction, in-hospital mortality