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Efthimiou, P., Kontzias, A., Hur, P., Rodha, K., Ramakrishna, G. S., and Nakasato, P., “Adult-Onset Still’s Disease in Focus: Clinical Manifestations, Diagnosis, Treatment, and Unmet Needs in the Era of Targeted Therapies.”

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Article

Adult-onset Still’s Disease, a Challenging Diagnosis of Exclusion

1University of Nevada Reno, Department of Internal Medicine, Reno, NV

2University of Minnesota, Department of Internal Medicine, Minneapolis, MN

3University of Texas Health Science Center at Houston, Department of Internal Medicine, Houston, TX


American Journal of Medical Case Reports. 2023, Vol. 11 No. 12, 172-175
DOI: 10.12691/ajmcr-11-12-2
Copyright © 2023 Science and Education Publishing

Cite this paper:
Su Hyun Jeong, Nishitha Shekhar, Matthew Amin, Amir Nabizadeh, Neelesh Mutyala. Adult-onset Still’s Disease, a Challenging Diagnosis of Exclusion. American Journal of Medical Case Reports. 2023; 11(12):172-175. doi: 10.12691/ajmcr-11-12-2.

Correspondence to: Su  Hyun Jeong, University of Nevada Reno, Department of Internal Medicine, Reno, NV. Email: suhyunj@unr.edu

Abstract

We report a case of Adult-onset Still’s Disease (AoSD) in a 55-year-old male without prior rheumatological history. The disease is an autoinflammatory condition with features including fevers, joint pain, and salmon-colored lesions. Diagnosis is through clinical classification systems including the Yamaguchi or Fautrel criteria and considered after a thorough diagnosis of exclusion. However, the disease is rare and difficult to recognize given its nonspecific presentation. This patient depicts the challenges in noticing the disease, especially in the setting of confounding physical exam findings. Prognosis is favorable, but prolonged periods without treatment can lead to the development of harmful complications including fulminant hepatitis, lymphohistiocytic activation syndrome, and disseminated intravascular coagulation.

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