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McNichol C. P., DeCicco E. M., Canfield A. M., Carstairs D. P., Paradine S. M. (2023). Copper-Catalyzed Aerobic Aminooxygenation of Cinnamyl N-Alkoxycarbamates via Substrate-Promoted Catalyst Activation. ACS Catalysis. 2023, 13(10): 6568-6573.

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Article

Copper-Catalyzed Hydroamination of Terminal Alkynes by Combining N-fluorobenzenesulfonimide and H2O: Synthesis of β-amino Substituted Styrenes

1Equipe de Chimie Organique et Analytique des Substances Bioactives, Faculté des Sciences et Techniques, Université Marien Ngouabi, Brazzaville, République du Congo BP 69

2Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Faculty of Chemistry, Northeast Normal University, Changchun 130024, China

3Laboratoire de Recherche en Chimie Appliquée, Ecole Normale Superieure, Université Marien Ngouabi, Brazzaville, République du Congo BP 69


World Journal of Organic Chemistry. 2023, Vol. 10 No. 1, 4-19
DOI: 10.12691/wjoc-10-1-2
Copyright © 2023 Science and Education Publishing

Cite this paper:
Tony Wheellyam Pouambeka, Hubert Makomo, Ghislain Kende, Timoléon Andzi Barhé. Copper-Catalyzed Hydroamination of Terminal Alkynes by Combining N-fluorobenzenesulfonimide and H2O: Synthesis of β-amino Substituted Styrenes. World Journal of Organic Chemistry. 2023; 10(1):4-19. doi: 10.12691/wjoc-10-1-2.

Correspondence to: Tony  Wheellyam Pouambeka, Equipe de Chimie Organique et Analytique des Substances Bioactives, Faculté des Sciences et Techniques, Université Marien Ngouabi, Brazzaville, République du Congo BP 69. Email: tonywheellyam@yahoo.fr

Abstract

By using the combining of N-fluorobenzenesulfonimide and H2O, we have realized the first example of high efficient and easy hydroamination of terminal alkynes. The reaction was catalyzed by copper and the corresponding β-amino substituted styrenes have been afforded in good to excellent yields. The transformation under simple mild conditions feature a broad substrate scope, atom economy, good functional group tolerance and the simple mechanism was proposed. The different products obtained were characterized using 1HNMR, 13CNMR and HRMS.

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