Hugh James Freeman^1,, James Gray¹

Recently, a male patient, presented to multiple medical specialties that eventually led to development of diarrhea and weight loss followed by eventual review by a gastroenterologist and a specific diagnosis of Whipple’s disease, a systemic disorder first described more than a century ago, but only recently recognized to be caused by Tropheryma whipplei. In this report, an updated review of this apparently very rare clinical disorder was done, including studies permitting a specific diagnosis of this disorder along with exclusion of other intestinal mucosal disorders that may potentially mimic Whipple’s disease.

Whipple’s disease, Tropheryma whipplei, periodic acid Schiff positive macrophages, Mycobacterium avium-intracellulare. small intestinal malabsorption