Islamov Miralisher Sadriddinovich¹, Makhmudova Azizа Dzhumanovna¹, Kayumov Abdurakhmon Abdumavlyanovich¹, Berger Inna Viktorovna^1,

The aim of the work was to study the parameters of hemostasis and their pathogenetic relationship with pro-inflammatory cytokines in hematogenous thrombophilia. Materials and methods: to solve the problem, a prospective study was conducted for the period 2021-2022. The main group included 47 patients registered with the RSSPMC of hematology with diagnoses of chronic leukemia included in the group. The selected patients were aged 18 to 45 years with a history of thrombosis and 36 patients with thrombosis at the moment. The comparison group consisted of 30 practically healthy people. Results and conclusions: At present, in patients with thrombosis, the intensity of the synthesis of positive factors IL-6 and IL-8 prevails over the synthesis of other cytokines, while in the synthesis of negative cytokines TNFα significantly prevails, which apparently determines the severity of thrombosis. A pathogenetic relationship between increased IL-1β, TNF-α, and activation of procoagulant mechanisms in the blood of patients suffering from acute thrombosis was revealed.

chronic leukemia, cytokines, interleukins, hemostasis, thrombosis