Layth Al-Karaja^1,, Lamees Khalil¹, Besan M. Alsayied¹, Shahd T. Natsheh², Malak S. Khalil¹, Wajd A.D.Natsheh², Alaa Abdulwahab¹

Evans Syndrome is a rare autoimmune disorder characterized by the sequential presence of autoimmune hemolytic anemia and thrombocytopenia. Knowing whether an ES is primary or secondary is crucial. The coexistence of ES with other conditions such as hematological malignancies, systemic lupus erythematosus, and infections can affect how it is managed or affect its prognosis. Here we report Evans Syndrome case in a 6 years old female patient who presented with cough, shortness of breath, tachypnea, fever, epistaxis, prolonged bleeding, ecchymosis, and petechia all over the lower jaundice, limbs and trunk, pancytopenia, autoimmune hemolytic anemia (AIHA) and immune thrombocytopenic purpura (ITP), reticulocytosis, and hemolysis of transfused blood, with elevated inflammatory markers. There was no family history of hemolytic diseases. The patient was treated with IV IG, steroids (prednisone) with slight progression for one year, then cyclosporine with better response, and finally mycophenolate mofetil.

Evans syndrome, hemolytic anemia, thrombocytopenia