Nicole Prisca Makaya Dangui Nieko^{1, 2,}, Cyr Jonas Morabandza^{1, 3}, Moїse Doria Kaya-Ongoto^{1, 4}, Duchel Jeanedvi Kinouani Kinavouidi^{1, 4}, Prosvi-Esrom Bikouma Mbangou²

Aminoglycosides and fluoroquinolones are among the most used antibiotics in synergy with beta-lactams. The objective of this work was to detect genes associated with resistance to fluoroquinolones and aminoglycosides in multiresistant strains of enterobacteria responsible for urinary tract infections. The diffusion method was used for antimicrobial sensitivity test of strains. qnr and aac genes were detected by Polymerase Chain Reaction. A total of 128 enterobacterial strains were studied. Resistance to the antibiotic families tested was observed with a frequency greater than 50%. Aminoglycosides were the least active family among the antibiotics used, with a resistance rate of 69.53%. aac(6’)-Ib-cr and qnrS genes were detected at rates of 34.09% and 22.72%, respectively. 13.63% of the strains showed coexpression of the qnr and aac genes. The detection of resistance genes to fluoroquinolones and aminoglycosides in enterobacterial strains isolated at the National Public Health Laboratory in Brazzaville could constitute a major concern in the therapeutic management of patients because it could lead to high costs for prolonged hospitalization.

Enterobacteriaceae, multidrug resistance, fluoroquinolones and aminoglycosides resistance genes, urinary tract infections