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Article

In vitro Anti-inflammatory and in vivo Immuno-modulatory Activities of Ethanolic Extract of Strychnos camptoneura (Loganiaceae) Seeds

1Laboratory of Microbiology, infectiology and Immunology, higher normal school, Marien Ngouabi University B.P. 69, Brazzaville (Congo)

2Laboratory of Biochemistry and Pharmacology, Heath Sciences Faculty, Marien Ngouabi University B.P. 69, Brazzaville (Congo)

3Laboratory of Biochemistry and Pharmacology, Heath Sciences Faculty, Marien Ngouabi University B.P. 69, Brazzaville (Congo);PEPITE (EA 4267), University of Bourgogne / Franche-Comté, Besançon 25000, France


American Journal of Pharmacological Sciences. 2022, Vol. 10 No. 1, 38-46
DOI: 10.12691/ajps-10-1-7
Copyright © 2022 Science and Education Publishing

Cite this paper:
Morabandza Cyr Jonas, Moulari Brice, Gombé Assoungou Hermann, Abena Ange Antoine. In vitro Anti-inflammatory and in vivo Immuno-modulatory Activities of Ethanolic Extract of Strychnos camptoneura (Loganiaceae) Seeds. American Journal of Pharmacological Sciences. 2022; 10(1):38-46. doi: 10.12691/ajps-10-1-7.

Correspondence to: Morabandza  Cyr Jonas, Laboratory of Microbiology, infectiology and Immunology, higher normal school, Marien Ngouabi University B.P. 69, Brazzaville (Congo). Email: moressejonas@gmail.com

Abstract

Strychnos camptoneura is an essential ethnomedicinal plant of the Congolese traditional medicine known to prevent, mitigate or treat the skin diseases. We aimed to investigate the in vitro anti-inflammatory effects of the S. camptoneura seeds ethanolic extract (EE), using the human keratinocytes and dermal fibroblast cells, and the in vivo immuno-modulatory effects. The in vitro anti-inflammatory activity was evaluated using the lipopolysaccharide-induced inflammation model. For the in vivo immuno-modulatory activities of ethanolic extract, immune cells were quantified by flow cytometer technique. The results showed that EE exhibited a higher anti-inflammatory activity compared to a non-treated group. The immuno-modulatory assay revealed that EE stimulate the immune cells (CD3, NK cells) and circulating anti-inflammatory cytokines (IL-10 and IL-4). These results could constitute a scientific basis for using S. camptoneura in traditional medicine.

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