Ahmed Saad¹, Medhat Anwar¹, Rabie Ramadan¹, Hajer Hassan^1,

Background: Lipofilling has become a widely used procedure in breast delayed reconstruction, after mastectomy, or breast conservative therapy, or autologous flap reconstruction. Main limitation is high reabsorption rate and local complications. The aim of this study is to evaluate the possible enhancement of the lipoinjectate to overcome these limitations. Methods: Between years 2017 and 2021, patients with PRP-enhanced lipofilling (Coleman technique) for correction (delayed) of different deformities after different surgical procedures used for breast cancer, (+-6 months after radiotherapy). Results: We performed the technique Platelet Rich Plasma enhanced lipoinjection after different surgical procedures used for breast cancer for 50 females, in which 20 patients underwent previous Breast Conservative therapy, 14 patients underwent modified radical mastectomy, and 16 patients had autologous flap reconstruction. Duration of operation 60-260 minutes, oil cysts 4%, fat necrosis 18%, microcalcifiaction 2%, absorption rate 31%, patient satisfaction (very satisfied) 42%. Conclusion: Although further investigations at the cellular level are needed, the results support the fact that PRP enhances the lipoinjectate subjectively, with lesser reabsorption rate and complications.

PRP, Lipofilling, breast reconstruction, reabsorption rate