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Puelles VG, Lütgehetmann M, Lindenmeyer MT, et al. Multiorgan and Renal Tropism of SARS-CoV-2. N Engl J Med 2020; 383(6): 590-2.

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Article

SARS-CoV-2 Related ANCA-associated Vasculitis and Pauci-Immune Glomerulonephritis

1Hemet Global Medical Center, Department of Internal Medicine, Hemet, CA, USA

2American University of Antigua College of Medicine, Saint Johns, AG

3Western University of Health Sciences College of Osteopathic Medicine of the Pacific, Pomona, CA, USA


American Journal of Medical Case Reports. 2022, Vol. 10 No. 5, 122-127
DOI: 10.12691/ajmcr-10-5-2
Copyright © 2022 Science and Education Publishing

Cite this paper:
Elli Novatcheva, Simranjit Randhawa, Aaron Safarian, Rocky Li, Chukwuemeka Umeh, Ryan Basak, Pranav Barve, Sumanta Chaudhuri, Sabina Kumar. SARS-CoV-2 Related ANCA-associated Vasculitis and Pauci-Immune Glomerulonephritis. American Journal of Medical Case Reports. 2022; 10(5):122-127. doi: 10.12691/ajmcr-10-5-2.

Abstract

COVID-19 is primarily a pulmonary disease characterized by both pulmonary and extrapulmonary complications. While acute respiratory distress syndrome (ARDS) is the most common pulmonary complication, acute kidney injury is the most common extrapulmonary complication of acute COVID-19. In addition, COVID-19 is associated with a cytokine storm capable of stimulating an autoimmune disorder. Here we present an unusual case of P-ANCA associated vasculitis and diffuse, pauci-immune rapidly progressive glomerulonephritis in a 24-year-old COVID-19 patient, resulting in an (AKI) requiring hemodialysis. The patient improved clinically after starting hydrocortisone and rituximab. She was, however, still dependent on hemodialysis at the time of hospital discharge.

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