John Edoka Raphael^1,, Kufre Udo¹

Background: Obstructive uropathy and urinary tract infection increase the risk of infection and renal scarring. When there is an obstruction in the urinary tract, stasis of urine with multiplication and ascending translocation of bacteria can result in urinary tract infection. These may present as cystitis, pyelonephritis, abscess formation and urosepsis. Treatment requires appropriate antibiotic treatment following urine culture and sensitivity to prevent potentially fatal urosepsis. Objectives: To evaluate the bacteria isolated in the urine culture of patients with obstructive uropathy and determine the common organisms associated with upper and lower urinary tract obstruction. Methods and Methodology: The study was an 8year retrospective evaluation of patients presenting with obstructive uropathy from two hospitals. All patients with upper and urinary tract obstructive uropathy were included. Their laboratory request forms and results of culture and sensitivity were reviewed. The data was extracted from records, coded into Excel, and analyzed using SPSS Version 20. Results: 445 patients with obstructive uropathy had their urine culture reports analyzed in the study population. The ages range from 2years to 108years with a mean age of 58years and a median age of 61years. 397(89.2%) were male, and 48(10.8%) were females. The urine positive culture rate was 70.6%. Gram-negative organisms were the commonest, with Klebsiella sp. 105(23.6%) the most frequently isolated. Escherichia Coli 98(22.0%). Citrobacter sp was the least common pathogen isolated and was not observed in females. Conclusion: Gram-negative organisms are the commonest pathogens cultured from the urine in patients with obstructive uropathy. The positive culture rate was 70.6%. Klebsiella sp. and E. Coli were the most prevalent organisms from the urine in patients with upper and lower urinary tract obstruction.

Gram-Negative, Obstructive Uropathy, Urine culture, UTI