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M. Mordstein, G. Kochs, L. Dumoutier, J.C. Renauld, S.R. Paludan, K. Klucher, P. Staeheli, Interferon-λ contributes to innate immunity of mice against influenza A virus but not against hepatotropic viruses, PLoS Pathog. (2008).

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Article

Protective Effect of Rosmarinic Acid on Influenza Virus-induced Pneumonia in Mice

1Department of Nursing, Wenjiang District People's Hospital of Chengdu, Chengdu, Sichuan, 611130, China


Journal of Food and Nutrition Research. 2022, Vol. 10 No. 2, 105-110
DOI: 10.12691/jfnr-10-2-4
Copyright © 2022 Science and Education Publishing

Cite this paper:
Xiuqiong Hu, Qin Hua, Lanjie Liu, Wei Yang. Protective Effect of Rosmarinic Acid on Influenza Virus-induced Pneumonia in Mice. Journal of Food and Nutrition Research. 2022; 10(2):105-110. doi: 10.12691/jfnr-10-2-4.

Correspondence to: Wei  Yang, Department of Nursing, Wenjiang District People's Hospital of Chengdu, Chengdu, Sichuan, 611130, China. Email: w0308yy@sina.com

Abstract

Influenza virus induces pneumonia or flu in living body, and the progress is severely dependent on the host immune system, environmental factors and strain for infection. H1N1 Pneumonia progresses quickly in the living organism, leading to severe respiratory failure or refractory pneumonia, with greater mortality than bacterial pneumonia. Rosmarinic acid has known for its an anti-inflammatory and anti-viral effect. The current investigation was designed to scrutinize the protective effect of Rosmarinic acid on influenza virus-induced pneumonia in mice and explore the possible mechanism. The protective effect of Rosmarinic acid was assessed on influenza induced virus infection in mice. The survival rats, virus yield and mean survival time were also estimated. Pro-inflammatory cytokines such as interleukin-10 (IL-10), interferon-γ (INF-γ), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) were scrutinized in the serum and lung tissue. NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3), adaptor apoptosis-associated speck-like protein containing a CARD (ASC) and Caspase-1 level also estimated. Rosmarinic acid considerably increased the survival rate, decreases the virus yields and prolongs survival., Rosmarinic acid significantly (P<0.001) up-regulated the INF-γ, IL-10 and down-regulated the level of IL-6 and TNF-α in the serum and lung tissue. Rosmarinic acid significantly reduced the expression of NLRP3, ASC and Caspase-1. Based on the obtained result, we can conclude that Rosmarinic acid exhibited a protective effect against the virus infection through inflammatory reaction.

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