Sepehr Sadafi^{1, 2}, Farhad Amirian^{1, 2}, Seyed Hamid Madani^{1, 2}, Mazaher Ramezani^{1, 2,}

Primary pancreatic lymphoma (PPL) is a very rare malignancy. The diagnosis of PPL is challenging because of similar manifestations to pancreatic adenocarcinoma or other diseases of the pancreas. It is mainly seen in men and the 5th or 6th decades of life. Here we report a 60-year-old lady with pancreatic mass, presented with abdominal pain, weight loss, and GI disturbance. An abdominal CT scan showed a homogenous mass, measured 60mm, in the lesser sac with the probable origin of the pancreatic body and a mass-like lesion on the head of the pancreas. Endoscopic ultrasound-assisted fine needle aspiration (EUS-FNA) was done and cell block was prepared for histopathology and immunohistochemistry evaluation. The final diagnosis of Large B cell lymphoma was made. The patient received an R-CHOP chemotherapy regimen with a good therapeutic response. Accurate diagnosis is important, due to response to chemotherapy and avoidance of unnecessary radical surgery.

primary pancreatic lymphoma, case report