Maximin Senou1,
,
Jacques Ezéchiel Lokonon1,
Germaine Ayitchehou1,
Félicienne Agbogba1, 2,
René J. Dehou1,
Espérance Medoatinsa1,
Pascal Tchogou1,
Boris Fresel Cachon1,
Alban Houngbeme3,
Eugène Attakpa4,
Amègnona Agbonon5,
Saïd Lamine Baba-Moussa6 1Laboratory of Experimental and Clinical Biology (LaBEC), National School of Applied Biosciences and Biotechnologies (ENSBBA), National University of Sciences, Technologies, Engineering and Mathematics (UNSTIM), R. Benin
2Laboratoire de Biologie Appliquée (LARBA), Ecole Polytechnique d’Abomey-Calavi (EPAC), Université d’Abomey-Calavi (UAC), R Bénin
3Laboratoire National de Pharmacognosie/Centre Béninois de la Recherche Scientifique et Technique (CBRST). BP 06 Oganla Porto-Novo, R Benin
4Laboratoire de Physiopathologie Moléculaire et Toxicologie de la Faculté des Sciences et Techniques (FAST) de l’Université d’Abomey-Calavi (UAC), R Benin
5Laboratoire de Physiologie/Pharmacologie, Faculté des Sciences, Université de Lomé, R. Togo
6Laboratory of Biology and Molecular Typing in Microbiology, University of Abomey-Calavi 01 BP 188 Cotonou, R Benin
American Journal of Medical Sciences and Medicine.
2021,
Vol. 9 No. 4, 115-119
DOI: 10.12691/ajmsm-9-4-4
Copyright © 2021 Science and Education PublishingCite this paper: Maximin Senou, Jacques Ezéchiel Lokonon, Germaine Ayitchehou, Félicienne Agbogba, René J. Dehou, Espérance Medoatinsa, Pascal Tchogou, Boris Fresel Cachon, Alban Houngbeme, Eugène Attakpa, Amègnona Agbonon, Saïd Lamine Baba-Moussa. Antidiabetic Activity of Aqueous Extracts of
Laurus nobilis, a Spice Used by Beninese Traditional Therapists.
American Journal of Medical Sciences and Medicine. 2021; 9(4):115-119. doi: 10.12691/ajmsm-9-4-4.
Correspondence to: Maximin Senou, Laboratory of Experimental and Clinical Biology (LaBEC), National School of Applied Biosciences and Biotechnologies (ENSBBA), National University of Sciences, Technologies, Engineering and Mathematics (UNSTIM), R. Benin. Email:
senouxim@yahoo.frAbstract
All over the world, humans developed knowledge about the use of medicinal plants to treat all kinds of diseases. Spices were included. This work aimed to evaluate the hypoglycemic property Laurus nobilis, a spice used by traditional therapists in Benin for diabetes management. The aqueous extracts of the leaves of Laurus nobilis were obtained by maceration. The phytochemical screening was carried out. Acute oral toxicity tests by single dose gavage of 2000 mg / kg body weight were performed in female Wistar rats. The weight of the animals, the serum creatinine, the ALT transaminase and the hemoglobin level were determined on day 0 and then on day 14. For the efficacy test, the extract was administered to rats at a concentration of 300 mg / Kg of body weight for 21 consecutive days. The blood tests performed were blood sugar, triglycerides and cholesterol. Histological sections were taken from the liver, kidneys and spleen. The phytochemical screening revealed the presence of tannins, mucilages and flavonoids. There were no deaths of rats and their weights, blood creatinine, ALT transaminase, and hemoglobin levels did not vary significantly during the toxicity study, indicating no toxicity. Regarding the efficacy test, Laurus nobilis extract significantly lowered the mean blood sugar level in rats on day 14 and day 21 (P <0.05) while the mean triglyceride and cholesterol levels total did not significantly change during the experiment. Laurus nobilis displayed hypoglycemic properties in non-diabetic rats and was not acutely toxic. It could be used in the management of diabetes.
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