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Davies MA, Kim SJ, Parikh NU, Dong Z, Bucana CD, Gallick GE. Adenovira-mediated expression of MMAC/PTEN in hibitsproliferation and metastasis of human prostate cancer cells. Clinical Cancer Research. 2002; 8(6): 1904-14.

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Article

Research Progress on the Correlation between PTEN and Tumors

1Shandong New Medicine Research Institute of Integrated Traditional and Western Medicine, Jinan, Shandong Province, 250101

2Interventional Hospital of Shandong Red Cross Society, Jinan, Shandong Province, 250101


American Journal of Biomedical Research. 2021, Vol. 9 No. 1, 19-23
DOI: 10.12691/ajbr-9-1-4
Copyright © 2021 Science and Education Publishing

Cite this paper:
Xiaohui Cui, Shufeng Du, Rongrong Li, Xiaoxia Jiang, Taihua Wang. Research Progress on the Correlation between PTEN and Tumors. American Journal of Biomedical Research. 2021; 9(1):19-23. doi: 10.12691/ajbr-9-1-4.

Correspondence to: Taihua  Wang, Shandong New Medicine Research Institute of Integrated Traditional and Western Medicine, Jinan, Shandong Province, 250101. Email: ganxibaowangtaihua@163.com

Abstract

PTEN is a tumor suppressor gene with dual specific phosphatase activity discovered after p53. and its deletion and mutation are closely related to the occurrence of a variety of malignant tumors. PTEN regulates cell proliferation, survival, and metabolism by inhibiting the activity of the PI3K/Akt signaling pathway, many components of which have been found to be involved in tumorigenesis. Although the mechanisms by which PTEN function is disrupted are diverse, the most frequently observed events are deletion of a single gene copy of PTEN. In this paper, the data relating to PTEN loss in some common tumour types and the related treatment of tumors are reviewed.

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