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Ikeda S, Arita M, Misaki K et al.: Incidence and impact of interstitial lung disease and malignancy in patients with polymyositis, dermatomyositis, and clinically amyopathic dermatomyositis: a retrospective cohort study. Springerplus. 2015, 4: 240.

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Article

An Unusual Case of Secondary Pulmonary Alveolar Proteinosis in Recently Diagnosed Anti-MDA5 Positive Amyopathic Dermatomyositis

1Internal Medicine, The Wright Center For Graduate Medical Education, Scranton, PA, USA

2Internal Medicine, Conemaugh Memorial Medical Center/Temple University, Johnstown, PA, USA


American Journal of Medical Case Reports. 2021, Vol. 9 No. 9, 438-440
DOI: 10.12691/ajmcr-9-9-1
Copyright © 2021 Science and Education Publishing

Cite this paper:
Komal Ejaz, Mousa Thalji, Muhammad Ali Raza, Hassan Awais. An Unusual Case of Secondary Pulmonary Alveolar Proteinosis in Recently Diagnosed Anti-MDA5 Positive Amyopathic Dermatomyositis. American Journal of Medical Case Reports. 2021; 9(9):438-440. doi: 10.12691/ajmcr-9-9-1.

Correspondence to: Komal  Ejaz, Internal Medicine, The Wright Center For Graduate Medical Education, Scranton, PA, USA. Email: ejazk@thewrightcenter.org

Abstract

Amyopathic dermatomyositis (AMD) is a subtype of dermatomyositis characterized by more prominent involvement of the skin rather than muscle and often positive for melanoma differentiation-associated gene 5 (MDA-5) antibodies. The most frequent pulmonary involvement in MDA-5 positive AMD is nonspecific interstitial pneumonia. However, rare cases of pulmonary alveolar proteinosis (PAP) have also been reported. Here, we present a case of a 28-year-old male who was recently diagnosed with AMD presenting with shortness of breath and dry cough was eventually diagnosed with secondary pulmonary alveolar proteinosis. This case underscores the multidisciplinary approach and diagnostic challenges associated with the diagnosis of PAP secondary to the rarity of the condition.

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