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Renal pathology of Waldenström's macroglobulinaemia with monoclonal antiglomerular antibodies and nephrotic syndrome. Lindström FD, Hed J, Eneström SClin Exp Immunol. 1980; 41(2): 196.

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Article

Light Chain Cast Nephropathy in an African-American Woman with Waldenström’s Macroglobulinemia

1Department of Internal Medicine- Division of Nephrology, Wayne State University

2Department of internal medicine, Wayne State University

3Department of internal medicine, Beaumont Health System


American Journal of Medical Case Reports. 2021, Vol. 9 No. 3, 167-169
DOI: 10.12691/ajmcr-9-3-9
Copyright © 2021 Science and Education Publishing

Cite this paper:
Mohamedanwar Ghandour, Ahmed Abdalrahem, Hammam Shereef, Yahya Osman-Malik, Hillel Sternlicht. Light Chain Cast Nephropathy in an African-American Woman with Waldenström’s Macroglobulinemia. American Journal of Medical Case Reports. 2021; 9(3):167-169. doi: 10.12691/ajmcr-9-3-9.

Correspondence to: Mohamedanwar  Ghandour, Department of Internal Medicine- Division of Nephrology, Wayne State University. Email: mr.anwar90@yahoo.com

Abstract

Waldenström's macroglobulinemia (WM) is a rare cancer of the lymphatic system due to excess IgM monoclonal protein with a rare renal involvement. We describe a case of MW presenting with acute renal failure. A 63-year-old female who was admitted to our hospital for influenza B complicated by acute renal failure during the hospital stay, with creatinine up to 6 mg/dL, despite adequate hydration. Electrophoresis revealed a monoclonal component in the gamma region, which was classified as an IgM k. A kidney biopsy was performed, showing light cast chains suggested the possibility of myeloma kidney. Furthermore, bone marrow histology was performed, revealing lymphoplasmacytic lymphoma. The patient was treated with bortezomib, dexamethasone, and cyclophosphamide, with complete recovery of renal function (creatinine 1.1 mg/dL).

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