1Institute of Medical Technology, Xiangtan Medicine and Health Vocational College, China
2School of Pharmacy, Dali University, China
American Journal of Medical Case Reports.
2021,
Vol. 9 No. 2, 116-121
DOI: 10.12691/ajmcr-9-2-5
Copyright © 2020 Science and Education PublishingCite this paper: YIN Ai-wu, GAO Peng-fei. Antidiabetic Activity of
Anemarrhena asphodeloides Bge. Polysaccharides.
American Journal of Medical Case Reports. 2021; 9(2):116-121. doi: 10.12691/ajmcr-9-2-5.
Correspondence to: YIN Ai-wu, Institute of Medical Technology, Xiangtan Medicine and Health Vocational College, China. Email:
yinaiwujs@sina.cnAbstract
The present study was aimed to investigate the anti-diabetic activity of Anemarrhena asphodeloides Bge. Polysaccharides (AAP). Wistar rats were injected with streptozotocin(STZ)to induce diabetes. The APP was prepared at first. After the rats were orally administered for 28 days, related biochemical indicator were determined. AAP was composed of mannose, galacturonic acid, galactose, glucose and xylose in the molar ratio of 12:8.1:2.7:1.3:1 with the average molecular weight of 52.4 kDa. After treatment with AAP (100 and 200 mg·kg-1) for 28 days there was a significant decrease in blood glucose, SGPT, SGOT, ALP, TC, TG, LDL, BUN and significant increase in body weight, fasting serum insulin, pancreatic insulin and HDL. The activities of SOD and CAT in liver and kidneys also increased. The results of the experiments showed that AAP exerted significant anti-diabetic activity.
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