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Rattenberry W, McDonough C H, Burger P C, Cohen K J (2011) Medulloblastoma with myogenic differentiation: long-term survival in a patient treated with aggressive combination therapy and autologous stem cell transplantation. J Neurooncol 105: 659-662.

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Article

Adult Large Cell/Anaplastic Medulloblastoma with Myogenic Differentiation: Case Report with Molecular Analysis

1Histopathology Department, Directorate General of Khoula Hospital, Muscat, Oman

2Division of Pathology, St. Michael’s Hospital, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

3Division of Neurosurgery, St. Michael’s Hospital, Department of Surgery, Toronto, Ontario, Canada


American Journal of Medical Case Reports. 2021, Vol. 9 No. 1, 71-74
DOI: 10.12691/ajmcr-9-1-18
Copyright © 2020 Science and Education Publishing

Cite this paper:
Simin Laiq, Jaragh M, Ginsberg H, David G Munoz. Adult Large Cell/Anaplastic Medulloblastoma with Myogenic Differentiation: Case Report with Molecular Analysis. American Journal of Medical Case Reports. 2021; 9(1):71-74. doi: 10.12691/ajmcr-9-1-18.

Correspondence to: Ginsberg  H, Division of Neurosurgery, St. Michael’s Hospital, Department of Surgery, Toronto, Ontario, Canada. Email:

Abstract

Medulloblastoma with myogenic differentiation (MMD), previously termed medullomyoblastoma, is a distinctive subtype of medulloblastoma. It is an uncommon neoplasm in children and very rare in adults, with oldest reported case being 49-years of age. We present a case of large cell/anaplastic medulloblastoma with myogenic differentiation arising in the right cerebellar hemisphere of a 54-year-old man treated by surgical resection and radiotherapy. Despite C-MYC amplification in the tumor, he survived tumor-free for nearly 2 years (726 days), which greatly exceeded the expected total survival. His death was attributed to complications of treatment rather than recurrence.

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