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Arbuckle MR, McClain MT, Rubertone MV, Scofield RH, Dennis GJ, James JA, Harley JB. Development of auto antibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med. 2003; 349:1526-1533.

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Article

Ribosomal P Antibodies Preceding the Onset of Sle-A Case Report


American Journal of Clinical Medicine Research. 2013, Vol. 1 No. 2, 26-27
DOI: 10.12691/ajcmr-1-2-1
Copyright © 2013 Science and Education Publishing

Cite this paper:
Prashanth N C, Satyanarayana. N, T. AnilKumar, Ravikumar. R. Ribosomal P Antibodies Preceding the Onset of Sle-A Case Report. American Journal of Clinical Medicine Research. 2013; 1(2):26-27. doi: 10.12691/ajcmr-1-2-1.

Correspondence to: T. AnilKumar, . Email:

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by the Production of auto antibodies directed against a variety of nuclear and cytoplasmic antigens. Auto antibodies to ribosomal Proteins are found in 15–30% of systemic lupus erythematosus (SLE) patients. Ribosomal P antibody is shown to predict SLE 1.7 years before clinical onset of SLE. This is a case of 28 year old female patient with a malar rash and nonspecific neurologic symptoms .The antibody profile showed that ANA ,anti- Ds dna and anti- Sm antibodies were negative but anti ribosomal P0 antibody was strongly positive(+++) at presentation. A strong clinical suspicion and careful follow-up helped in making a diagnosis of SLE over a period of nine months.

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