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Sato T, Uchiumi T, Ozawa T, Kikuchi M, Nakano M, Kominami R, Arakawa M. Auto antibodies Against ribosomal proteins found with high frequency in patients with systemic lupus Erythematosus with active disease. The Journal of rheumatology. 1991; 18:1681-1684.

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Ribosomal P Antibodies Preceding the Onset of Sle-A Case Report

American Journal of Clinical Medicine Research. 2013, Vol. 1 No. 2, 26-27
DOI: 10.12691/ajcmr-1-2-1
Copyright © 2013 Science and Education Publishing

Cite this paper:
Prashanth N C, Satyanarayana. N, T. AnilKumar, Ravikumar. R. Ribosomal P Antibodies Preceding the Onset of Sle-A Case Report. American Journal of Clinical Medicine Research. 2013; 1(2):26-27. doi: 10.12691/ajcmr-1-2-1.

Correspondence to: T. AnilKumar, . Email:


Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by the Production of auto antibodies directed against a variety of nuclear and cytoplasmic antigens. Auto antibodies to ribosomal Proteins are found in 15–30% of systemic lupus erythematosus (SLE) patients. Ribosomal P antibody is shown to predict SLE 1.7 years before clinical onset of SLE. This is a case of 28 year old female patient with a malar rash and nonspecific neurologic symptoms .The antibody profile showed that ANA ,anti- Ds dna and anti- Sm antibodies were negative but anti ribosomal P0 antibody was strongly positive(+++) at presentation. A strong clinical suspicion and careful follow-up helped in making a diagnosis of SLE over a period of nine months.