Article citationsMore >>

Muthumani, P., Neckmohammed., Meera R., Venkataraman, S., Chidambaranathan, N., Devi, P. and Suresh Kumar, C.A. Synthesis and evaluation of anticonvulsant and antimicrobial activities of some Mannich bases of substituted aminophenol and acetophenone. Int. J. Pharm. Biomed. Res., 2010, 1(3). 78-86.

has been cited by the following article:

Article

In-vivo Anticonvulsant and In-vitro Antimycobacterial Activities of 6-Aryl Pyridazine-3(2H)-One Derivatives

1Department of Pharmacy, GRD (P.G) Institute of Management & Technology, Dehradun, India

2Department of Pharmaceutical sciences, Kumaun University, Bheemtal, Nainital, India


American Journal of Pharmacological Sciences. 2014, Vol. 2 No. 1, 1-6
DOI: 10.12691/ajps-2-1-1
Copyright © 2014 Science and Education Publishing

Cite this paper:
Mohammad Asif, Anita Singh, Lakshmayya. In-vivo Anticonvulsant and In-vitro Antimycobacterial Activities of 6-Aryl Pyridazine-3(2H)-One Derivatives. American Journal of Pharmacological Sciences. 2014; 2(1):1-6. doi: 10.12691/ajps-2-1-1.

Correspondence to: Mohammad  Asif, Department of Pharmacy, GRD (P.G) Institute of Management & Technology, Dehradun, India. Email: aasif321@gmail.com

Abstract

Some 6-aryl-4,5-dihydropyridazin-3(2H)-one compounds (2a-f) were synthesized and evaluated for their in-vivo anticonvulsant activities against maximal electro shock (MES) and isoniazid (INH) induced seizure methods at 50mg/kg dose level. Neurotoxicity of all compounds (2a-f) was also tested at 50, 100 and 200mg/kg dose level. The in-vitro antitubercular activity was evaluated against Mycobacterium tuberculosis H37Rv by using the Microplate Alamar Blue Assay (MABA) method. The result showed that all compounds (2a-f) showed significant anticonvulsant activity against both MES and INH induced convulsion methods. Among all compounds (2a-f), highest activity was exhibited by compound 2e against MES and compound 2b against INH-induced convulsion methods. In both methods, phenytion sodium (25mg/kg) and sodium valproate (50mg/kg) were used as reference drugs. All compounds did not showed any neurotoxicity up to 200mg/kg dose level. In antitubercular activity, minimum inhibitor concentration of compound 2e and 2f was 12.5μg/ml and other remaining compounds (2a-d) were showed 25μg/ml when compared with reference drugs Isoniazid (3.12μg/ml), Pyrizinamide (3.12μg/ml) and Streptomycin (6.25μg/ml).

Keywords