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Article

On the Mechanism of the Serullas Test for Morphine

1Organic Chemistry Department, Faculty of Chemistry, National Autonomous University of Mexico, Mexico City (CDMX), Mexico


World Journal of Organic Chemistry. 2020, Vol. 8 No. 1, 7-10
DOI: 10.12691/wjoc-8-1-3
Copyright © 2020 Science and Education Publishing

Cite this paper:
Francisco Sánchez-Viesca, Reina Gómez. On the Mechanism of the Serullas Test for Morphine. World Journal of Organic Chemistry. 2020; 8(1):7-10. doi: 10.12691/wjoc-8-1-3.

Correspondence to: Francisco  Sánchez-Viesca, Organic Chemistry Department, Faculty of Chemistry, National Autonomous University of Mexico, Mexico City (CDMX), Mexico. Email: franviesca@yahoo.com

Abstract

The reaction of iodic acid with morphine (Serullas colour test) has not been studied. It is a very sensitive reaction published in France that had a great resonance in Europe and in the United States. However, there is no reaction mechanism advanced. We provide the electron flow, step by step, of this oxidation of morphine. An aromatic hydroxylation and then ortho-quinone formation are described. This spot test opens a route to o-quinones from phenols, and this is important. A brief Serullas’ profile and references of the test are included.

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