Background: Puberty is a period of rapid growth and hormonal changes and is often characterized by deterioration in glycemic control, and all of these factors may promote the development of diabetes complications. Type 1 diabetes mellitus (T1DM) is a chronic disease requiring complex management, including blood glucose monitoring, insulin administration along with diet restrictions, which can have a negative impact on the quality of life (QoL) of adolescents. The aim of the study: This study aimed to investigate the relationship between compliance and quality of life among adolescents with diabetes mellitus type 1. Design: A descriptive cross-sectional design was utilized in this study. Setting: This study was conducted at the outpatient clinics in Zagazig University Hospitals at the pediatrics unit and the health insurance clinic for diabetes in Zagazig city. Subjects: A convenient sample of 80 adolescents diagnosed with type 1 diabetes Three tools were used for data collection, namely; A structured interviewing questionnaire, Diabetes self-management profile, and Diabetes quality of life for youths scale. The results: Slightly more than half of adolescent had a moderate knowledge of diabetes mellitus (53.8%), the highest percentage of the study sample had inadequate levels of compliance to diabetes treatment recommendations and perceived their quality of life as low (61.3% & 67.5%, respectively). Conclusion: It was found that there was a statistically significant relation between adolescents' compliance and quality of life score. Recommendations: Conduct educational program for adolescents and their parents to increase the level of their knowledge and compliance for diabetes management to improve QOL for all diabetic adolescents.

adolescents, compliance, diabetes mellitus type 1, quality of life