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Petrinec, D., Liao, S., Holmes, D.R., Reilly, J.M., Parks, W.C., Thompson, R.W., “Doxycycline inhibition of aneurysmal degeneration in an elastase-induced rat model of abdominal aortic aneurysm: preservation of aortic elastin associated with suppressed production of 92 kD gelatinase,” Journal of vascular surgery 23(2). 336-46. 1996.

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Article

Role of Matrix Metalloproteinases (MMPs) and MMP Inhibitors on Intracranial Aneurysms (A Review Article)

1Brain and spinal injury repair research center (BASIR). Tehran University of medical sciences, Tehran, Iran

2Department of general Surgery, Rasoul akram hospital,Tehran University of medical sciences, Tehran, Iran

3Brain and spinal injury repair research center (BASIR), Department of neurosurgery, Tehran University of Medical Sciences, Tehran, Iran


American Journal of Pharmacological Sciences. 2013, Vol. 1 No. 5, 100-103
DOI: 10.12691/ajps-1-5-6
Copyright © 2013 Science and Education Publishing

Cite this paper:
Azam Maradni, Seyed Hasan Emamirazavi, Abbas Noruzi-javidan, Seyed Hamzeh Mousavi, Alireza Khoshnevisan. Role of Matrix Metalloproteinases (MMPs) and MMP Inhibitors on Intracranial Aneurysms (A Review Article). American Journal of Pharmacological Sciences. 2013; 1(5):100-103. doi: 10.12691/ajps-1-5-6.

Correspondence to: Alireza  Khoshnevisan, Brain and spinal injury repair research center (BASIR), Department of neurosurgery, Tehran University of Medical Sciences, Tehran, Iran. Email: akhoshnevisan@yahoo.com

Abstract

Cerebrovascular disease is one of the leading causes of death in the world, and about one-fourth of cerebrovascular deaths are due to ruptured cerebral aneurysms (CA). Accordingly it is important to find a way to reduce aneurysm formation and its subsequent morbidity and mortality. Proteolytic activity capable of lysing gelatin has been shown to be increased in aneurysm tissue and expression of plasmin, membrane-type matrix metalloproteinase-1(MT1-MMP), and matrix metalloproteinase-2 (MMP-2) in aneurysmal wall is more than what we observe in normal cerebral arteries. This activity may induce focal degradation of the vascular extracellular matrix and may contribute to aneurysm formation and growth. MMPs are important in tissue remodeling associated with various physiological and pathological processes such as morphogenesis, angiogenesis, apoptosis and tissue repair. in this paper we review the role of MMPs in aneurysm formation.

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