1Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
International Journal of Celiac Disease.
2019,
Vol. 7 No. 2, 48-52
DOI: 10.12691/ijcd-7-2-7
Copyright © 2019 Science and Education PublishingCite this paper: Nastaran Asri, Mohammad Rostami-Nejad. The Facts of Celiac Disease; A Comprehensive Review.
International Journal of Celiac Disease. 2019; 7(2):48-52. doi: 10.12691/ijcd-7-2-7.
Correspondence to: Mohammad Rostami-Nejad, Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Email:
m.rostamii@gmail.comAbstract
Celiac disease (CD) is the most common permanent T-cell mediated gluten intolerance, caused by the dietary gluten in individuals who are genetically susceptible to the disease. CD characterized by small intestine mucosal lesions, subtotal, or total intestinal villi atrophy and nutrient malabsorptions. Sometimes the diagnosis of CD is so challenging and needs a combination of clinical, serological, histopathological and genetic evaluations. The well-known cornerstone treatment of CD is gluten-free diet (GFD) and there is need to regular monitoring of patients after starting the GFD. The main aim of this review was to discussing the definition and pathogenesis of CD, together with the diagnostics, treatment and follow-up strategies in this disease.
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