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Hutchison, C.A., “Batuman V, Behrens J, et al. The pathogenesis and diagnosis of acute kidney injury in multiple myeloma,” Nat Rev Nephrol, 8 (1). 43-51. 2011.

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Article

Nephrotoxicity Induced by Cytosar in Rabbits Kidneys (A Histological Study)

1Basic Sciences, College of Dentistry\Mosul University, Mosul, Iraq


American Journal of Medical and Biological Research. 2019, Vol. 7 No. 1, 1-5
DOI: 10.12691/ajmbr-7-1-1
Copyright © 2019 Science and Education Publishing

Cite this paper:
Saif Al-Jammas. Nephrotoxicity Induced by Cytosar in Rabbits Kidneys (A Histological Study). American Journal of Medical and Biological Research. 2019; 7(1):1-5. doi: 10.12691/ajmbr-7-1-1.

Correspondence to: Saif  Al-Jammas, Basic Sciences, College of Dentistry\Mosul University, Mosul, Iraq. Email: saifaljammas@uomosul.edu.iq

Abstract

The current study was carried out to assess the nephrotoxicity induced by Cytosar in kidneys of rabbits from the histological aspect. The treated group with a dose of (50 mg/kg/daily) of Cytosar for 5 days, showed clear histological changes represented by glomerular atrophy and widening of Bowman’s spaces, infiltration of lymphocytes and macrophages within cortex, renal tubular necrosis, cortical hemorrhage and fibrosis as well as formation of tubular hyaline cast was also observed. The present study showed that Cytosar is a nephrotoxic drug when used repeatedly at this dosage which could lead to irreversible renal damage and finally renal failure.

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