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Hu WT, Murray JA, Greenaway MC, et al. Cognitive impairment and celiac disease. Arch Neurol. 2006 Oct; 63(10): 1440-1446.

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Neurological Complications of Coeliac Disease

1Department of Neurology, Wrocław Medical University, st. Borowska 213, 50-556 Wrocław

International Journal of Celiac Disease. 2019, Vol. 7 No. 1, 16-20
DOI: 10.12691/ijcd-7-1-8
Copyright © 2019 Science and Education Publishing

Cite this paper:
Justyna Chojdak-Łukasiewicz, Edyta Dziadkowiak, Małgorzata Błauciak, Bogusław Paradowski. Neurological Complications of Coeliac Disease. International Journal of Celiac Disease. 2019; 7(1):16-20. doi: 10.12691/ijcd-7-1-8.

Correspondence to: Justyna  Chojdak-Łukasiewicz, Department of Neurology, Wrocław Medical University, st. Borowska 213, 50-556 Wrocław. Email:


Coeliac disease (CD) is a chronic autoimmune enteropathy of the small intestine that occurs in genetically predisposed individuals. It is characterized by atrophy of intestinal villi accompanied by an increase in the number of intraepithelial lymphocytes and crypt hypertrophy as well as the presence of specific endomysial antibodies (EMA), IgA tissue transglutaminase antibodies (IgA-tTG), and IgA and IgG deaminated gliadin peptide antibodies (DGP IgA and IgG). CD is associated with a wide spectrum of clinical signs and symptoms secondary to malabsorption (vitamin deficiency, anaemia, osteoporosis) or unrelated to the gastrointestinal tract. Neurological disorders are a common problem in patients with CD and are not always accompanied by gastrointestinal symptoms. The most common neurological manifestations of CD are cerebellar ataxia, epilepsy, and peripheral neuropathy.