1Department of Internal Medicine, NYC Health and Hospitals/Jacobi Medical Center, Bronx, N.Y., U.S.A- 10461
2Department of Internal Medicine, State University of New York, Downstate Medical Center, Brooklyn, N.Y, U.S.A- 11203
American Journal of Medical Case Reports.
2019,
Vol. 7 No. 1, 9-12
DOI: 10.12691/ajmcr-7-1-3
Copyright © 2019 Science and Education PublishingCite this paper: Apoorva Jayarangaiah, Pramod Theetha Kariyanna, Tanuj Chokshi, Maya Srinivasan, Seline Asun, Michael Ashamalla, Irini Youssef, Samy I McFarlane. Leukocytosis Associated with Esophageal Squamous Cell Carcinoma as a Predictor of Poor Prognosis - A Case Report and Review of Literature.
American Journal of Medical Case Reports. 2019; 7(1):9-12. doi: 10.12691/ajmcr-7-1-3.
Correspondence to: Samy I McFarlane, Department of Internal Medicine, State University of New York, Downstate Medical Center, Brooklyn, N.Y, U.S.A- 11203. Email:
smcfarlane@downstate.eduAbstract
Leukocytosis, specifically granulocytosis in malignancy is a common finding with various etiologies. Graulocytosis associated with esophageal cancer has not commonly been reported in case reports in the United States. Furthermore, granulocyte colony stimulating factor (G-CSF) producing tumors have been associated with a variety of cancers. However, G-CSF producing esophageal tumors are rare. The diagnosis is established through serum G-CSF levels and immunohistochemistry staining of tumor cells. Here, we report a case of a 72-year-old woman with persistent granulocytosis leading to the diagnosis of esophageal squamous cell carcinoma (ESCC). Although, our case did not report serum G-CSF levels, we strongly suspect it to be the underlying etiology in our case. Additionally, through our missed opportunity, we hope to emphasize and increase awareness of G-CSF producing ESCC.
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