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Ogungbe, I.V. and Setzer, W.N., “The Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking Investigations”, Molecules, 21(10). pii: E1389. October 2016.

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Article

In vitro Antimicrobial Efficiency of Crude Extracts of Wild Jatropha glauca Plant Leaves Grown Naturally at Al-Baha Region, KSA

1Department of Chemistry, Faculty of Science, Albaha University, Albaha, KSA


World Journal of Organic Chemistry. 2018, Vol. 6 No. 1, 1-5
DOI: 10.12691/wjoc-6-1-1
Copyright © 2018 Science and Education Publishing

Cite this paper:
Mohammad Mahboob Alam, Sami A. Zabin, Syed Nazreen. In vitro Antimicrobial Efficiency of Crude Extracts of Wild Jatropha glauca Plant Leaves Grown Naturally at Al-Baha Region, KSA. World Journal of Organic Chemistry. 2018; 6(1):1-5. doi: 10.12691/wjoc-6-1-1.

Correspondence to: Sami  A. Zabin, Department of Chemistry, Faculty of Science, Albaha University, Albaha, KSA. Email: smaizabin@gmail.com, szabin@bu.edu.sa

Abstract

The crude extracts from leaves of Jatropha glauca plant grown naturally at Al-Baha region obtained by extraction with ethanol and fractionated using three solvents: petroleum ether, ethyl acetate and methanol were investigated for their in vitro antimicrobial susceptibility. The antimicrobial activity were evaluated against two bacterial strains S. aureus and E. coli, and two common fungal strains Candida albicans and Candida krusei using disc diffusion assay. The crude ethanolic extract and its fractions methanolic and ethyl acetate showed an inhibitory effect against both bacterial and fungal microorganisms. The petroleum ether fraction had no antimicrobial effect. The ethanolic crude extract and methanolic fraction showed higher zone of inhibition, while the ethyl acetate fraction showed the least activity against both bacterial strains. The methanolic fraction was found to possess lowest MIC ≥250 μgml−1 against both tested bacterial strains. Similarly, the ethanolic crude extract and methanol fraction showed zone of inhibition against tested fungal strains with methanolic fraction showed the highest zone of inhibition. However, these observations indicated that the ethanolic crude extract and its methanolic and ethyl acetate fractions exhibited some antimicrobial potency that proves the leaves contain some gradients that have antibacterial and antifungal potential.

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