Article citationsMore >>

A. Fabianska, A. Ofiarska, A. Fiszka-Borzyszkowska, P. Stepnowski, E.M. Siedlecka, Electrodegradation of ifosfamide and cyclophosphamide at BDD electrode: Decomposition pathway and its kinetics, Chem. Engin. Journal 276, 274-282, 2015.

has been cited by the following article:

Article

Mass Spectrometric Detection and Reductive Degradation of the Anti-cancer Drugs Ifosfamide and Cyclophosphamide

1Ludwigsburg University of Education, Department of Chemistry, Reuteallee 46, D-71634 Ludwigsburg, Germany

2University of Hildesheim, Hildesheim, Germany


Applied Ecology and Environmental Sciences. 2018, Vol. 6 No. 1, 15-22
DOI: 10.12691/aees-6-1-3
Copyright © 2018 Science and Education Publishing

Cite this paper:
C. Laauser, G. Habekost, A. Habekost. Mass Spectrometric Detection and Reductive Degradation of the Anti-cancer Drugs Ifosfamide and Cyclophosphamide. Applied Ecology and Environmental Sciences. 2018; 6(1):15-22. doi: 10.12691/aees-6-1-3.

Correspondence to: A.  Habekost, Ludwigsburg University of Education, Department of Chemistry, Reuteallee 46, D-71634 Ludwigsburg, Germany. Email: A.Habekost@t-online.de

Abstract

A flow tube reactor containing iron or zinc powder in a nitrogen atmosphere is capable of performing >90% anaerobic reductive dehalogenation of the cancer drugs ifosfamide and cyclophosphamide at 400 °C using toluene, alcohol or water as proton donors and iron or zinc as reducing agents. The products are all chlorine-free, as proven by GC-MS. The process is particularly interesting for large-scale industrial applications.

Keywords